I use a Scarlett 2i2 box with two mics into one USB on a macbook pro. Other clients detect both mics, but Descript seems to detect only one. This is the one thing keeping me from using Descript to directly record our podcast. (Right now we're recording into GarageBand, and I'm separately importing to Descript as an experiment, but this adds a whole 'nother program to the workflow)